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Dose response inhibition of Cobimetinib and Etrasimod across KRAS mutant nonsmall cell lung cancer cell lines. A, B) Dose response curve of Cobimetinib and Etrasimod for SKLU1, A427, and A549 cells. C) Table reports IC 50 values and maximal observed inhibition ( E max ) in each condition. Curves were determined as mean of triplicates and fitted to a four-parameter logistic dose–response curve. Data are means ± SEM.

Journal: ACS Omega

Article Title: Machine Learning-Driven Drug Repurposing for KRAS G12C and KRAS G12D Inhibition

doi: 10.1021/acsomega.5c12639

Figure Lengend Snippet: Dose response inhibition of Cobimetinib and Etrasimod across KRAS mutant nonsmall cell lung cancer cell lines. A, B) Dose response curve of Cobimetinib and Etrasimod for SKLU1, A427, and A549 cells. C) Table reports IC 50 values and maximal observed inhibition ( E max ) in each condition. Curves were determined as mean of triplicates and fitted to a four-parameter logistic dose–response curve. Data are means ± SEM.

Article Snippet: For the laboratory experiments, SKLU1 and A427 (KRAS G12D) and A549 (KRAS G12S) lung cancer cells were obtained from the American Type Culture Collection (ATCC) and maintained in standard culture conditions using basal media supplemented with 10% FCS and 1% penicillin–streptomycin.

Techniques: Inhibition, Mutagenesis